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Forkhead Transcription Factor <i>Foxq1</i> Promotes Epithelial–Mesenchymal Transition and Breast Cancer Metastasis

1 Feb 2011

Abstract excerpt

Epithelial-mesenchymal transition (EMT) promotes cancer invasion and metastasis, but the integrative mechanisms that coordinate these processes are incompletely understood. In this study, we used a cross-species expression profiling strategy in metastatic cell lines of human and mouse origin to identify 22 up-regulated and 12 down-regulated genes that are part of an essential genetic program in metastasis. In...

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PMID: 21285253
DOI: 10.1158/0008-5472.can-10-2825

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