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Article

Essential cysteine residues of the type IIa Na+/Pi cotransporter.

Pflugers Archiv : European journal of physiology - 1 May 2003

Köhler Katja, Forster Ian C, Stange Gerti, Biber Jürg, Murer Heini

Abstract excerpt

The rat renal Na(+)/P(i) cotransporter (NaP(i)-IIa) contains 12 native cysteines. When individually replaced by a serine, none appears essential for proper expression and function. Nevertheless, the formation of one essential cysteine bridge (C5/C6), together with a postulated second bridge, is necessary. To determine the minimum cysteine residues required for functional NaP(i)-IIa, with the goal of generating a...

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PMID: 12739158
DOI: 10.1007/s00424-003-1039-6

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