Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Involvement of phosphoinositide 3-kinase signaling pathway in chondrocytic differentiation of ATDC5 cells: application of a gene-trap mutagenesis.

Journal of cellular biochemistry - 1 Oct 2004

Ihara-Watanabe Miyuki, Uchihashi Takayuki, Miyauchi Yoshiteru, Sakai Norio, Yamagata Masayo, Ozono Keiichi, Michigami Toshimi

Abstract excerpt

Gene-trap mutagenesis is based on the notion that the random insertion of a trapping vector may disturb the function of inserted genes. Here, we applied this method to murine mesenchymal ATDC5 cells, which differentiate into mature chondrocytes in the presence of insulin. As the trap vector we used pPT1-geo, which lacks its own promoter and enhancer, but contains a lacZ-neo fusion gene as a reporter and selection...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Chondrocytes
Share to Chromones

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Enzyme Inhibitors

Share to Insulin

Share to Morpholines

Share to Phosphatidylinositol 3-Kinases

Share to Phosphoinositide-3 Kinase Inhibitors

Share to Protein Subunits

Source

Identifiers

PMID: 15368367
DOI: 10.1002/jcb.20185

Genes

PTH

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Involvement of phosphoinositide 3-kinase signaling pathway in chondrocytic differentiation of ATDC5 cells: application of a gene-trap mutagenesis.PMID 15368367Read ↗

Vinculin functions as regulator of chondrogenesis.Semantic proximity Read ↗

Proper expression of helix-loop-helix protein Id2 is important to chondrogenic differentiation of ATDC5 cells.Semantic proximity Read ↗

Rab23 regulates differentiation of ATDC5 chondroprogenitor cells.Semantic proximity Read ↗

Trps1 plays a pivotal role downstream of Gdf5 signaling in promoting chondrogenesis and apoptosis of ATDC5 cells.Semantic proximity Read ↗

Establishment of a novel chondrocyte-like cell line derived from transgenic mice harboring the temperature-sensitive simian virus 40 large T-antigen gene.Semantic proximity Read ↗

LGR5 Modulates Differentiated Phenotypes of Chondrocytes Through PI3K/AKT Signaling Pathway.Semantic proximity Read ↗

Insulin-like growth factor-1 rescues the mutated FGF receptor 3 (G380R) expressing ATDC5 cells from apoptosis through phosphatidylinositol 3-kinase and MAPK.Semantic proximity Read ↗

Role of the low-density lipoprotein receptor-related protein-1 in regulation of chondrocyte differentiation.Semantic proximity Read ↗

P5L mutation in Ank results in an increase in extracellular inorganic pyrophosphate during proliferation and nonmineralizing hypertrophy in stably transduced ATDC5 cells.Semantic proximity Read ↗

A novel gene trapping for identifying genes expressed under the control of specific transcription factors.Semantic proximity Read ↗

Molecular basis for the treatment of achondroplasia.Semantic proximity Read ↗

The inorganic pyrophosphate transporter ANK preserves the differentiated phenotype of articular chondrocyte.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.