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Article

Identification and Functional Characterization of Distinct Critically Important Bone Morphogenetic Protein-specific Response Elements in the Id1 Promoter

1 Feb 2002

Abstract excerpt

Transforming growth factor-beta (TGF-beta) family members, which include bone morphogenetic proteins (BMPs) and TGF-betas, elicit their cellular effects by activating specific Smad proteins, which control the transcription of target genes. BMPs and TGF-betas have overlapping as well as specific effects on mesenchymal cell differentiation for which the mechanisms are incompletely understood. Here we report that...

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PMID: 11729207
DOI: 10.1074/jbc.m111023200

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Identification and Functional Characterization of Distinct Critically Important Bone Morphogenetic Protein-specific Response Elements in the Id1 PromoterPMID 11729207Read ↗

Identification of a novel bone morphogenetic protein (BMP)-inducible transcript, BMP-inducible transcript-1, by utilizing the conserved BMP-responsive elements in the Id genesSemantic proximity Read ↗

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Id proteins are critical downstream effectors of BMP signaling in human pulmonary arterial smooth muscle cellsSemantic proximity Read ↗

Smad3 mediates immediate early induction of Id1 by TGF-βSemantic proximity Read ↗

Smad1 and Smad4 are components of the bone morphogenetic protein-4 (BMP-4)-induced transcription complex of the Xvent-2B promoter.Semantic proximity Read ↗

Genome-wide mechanisms of Smad bindingSemantic proximity Read ↗

The TGF-beta family mediator Smad1 is phosphorylated directly and activated functionally by the BMP receptor kinase.Semantic proximity Read ↗

Id1 represses osteoclast-dependent transcription and affects bone formation and hematopoiesis.Semantic proximity Read ↗

Tubular Epithelial Cell Dedifferentiation Is Driven by the Helix-Loop-Helix Transcriptional Inhibitor Id1Semantic proximity Read ↗

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