Article
The Psi(m) depolarization that accompanies mitochondrial Ca2+ uptake is greater in mutant SOD1 than in wild-type mouse motor terminals.
Proceedings of the National Academy of Sciences of the United States of America - 10 Feb 2009
Nguyen Khanh T, García-Chacón Luis E, Barrett John N, Barrett Ellen F, David Gavriel
Abstract excerpt
The electrical gradient across the mitochondrial inner membrane (Psi(m)) is established by electron transport chain (ETC) activity and permits mitochondrial Ca(2+) sequestration. Using rhodamine-123, we determined how repetitive nerve stimulation (100 Hz) affects Psi(m) in motor terminals innervating mouse levator auris muscles. Stimulation-induced Psi(m) depolarizations in wild-type (WT) terminals were small (<5...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.