Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Mitochondria in motor nerve terminals: function in health and in mutant superoxide dismutase 1 mouse models of familial ALS.

Journal of bioenergetics and biomembranes - 1 Dec 2011

Barrett Ellen F, Barrett John N, David Gavriel

Abstract excerpt

Mitochondria contribute to neuronal function not only via their ability to generate ATP, but also via their ability to buffer large Ca(2+) loads. This review summarizes evidence that mitochondrial Ca(2+) sequestration is especially important for sustaining the function of vertebrate motor nerve terminals during repetitive stimulation. Motor terminal mitochondria can sequester large amounts of Ca(2+) because they...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Amyotrophic Lateral Sclerosis
Share to Calcium

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Genetic Diseases, Inborn

Share to Mitochondria

Share to Motor Neurons

Share to Mutation, Missense

Share to Superoxide Dismutase

Share to Superoxide Dismutase-1

Source

Open in PubMed Open full text

Identifiers

PMID: 22089637
DOI: 10.1007/s10863-011-9392-1
PMCID: PMC3237816

Genes

SOD1

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Mitochondria in motor nerve terminals: function in health and in mutant superoxide dismutase 1 mouse models of familial ALS.PMID 22089637Read ↗

Mitochondria at the SynapseSemantic proximity Read ↗

Mitochondrial dysfunction and its role in motor neuron degeneration in ALS.Semantic proximity Read ↗

Mitochondrial Dyshomeostasis as an Early Hallmark and a Therapeutic Target in Amyotrophic Lateral SclerosisSemantic proximity Read ↗

Mitochondrial Transport and Turnover in the Pathogenesis of Amyotrophic Lateral SclerosisSemantic proximity Read ↗

The Psi(m) depolarization that accompanies mitochondrial Ca2+ uptake is greater in mutant SOD1 than in wild-type mouse motor terminals.Semantic proximity Read ↗

Mitochondrial Ca2+ and neurodegenerationSemantic proximity Read ↗

The Impact of Mitochondrial Dysfunction in Amyotrophic Lateral SclerosisSemantic proximity Read ↗

Mutant SOD1 in neuronal mitochondria causes toxicity and mitochondrial dynamics abnormalities.Semantic proximity Read ↗

Mitochondrial dysfunction is a converging point of multiple pathological pathways in amyotrophic lateral sclerosis.Semantic proximity Read ↗

Role of mitochondria in mutant SOD1 linked amyotrophic lateral sclerosis.Semantic proximity Read ↗

Skeletal muscle dysfunction in amyotrophic lateral sclerosis: a mitochondrial perspective and therapeutic approachesSemantic proximity Read ↗

Mitochondrial dysfunction in amyotrophic lateral sclerosis - a valid pharmacological target?Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.