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Article

Morphological and functional changes in innervation of a fast forelimb muscle in SOD1-G85R mice.

Neurobiology of disease - 1 Dec 2012

Nguyen Khanh T, Zhang Zhongsheng, Barrett Ellen F, David Gavriel

Abstract excerpt

Muscle endplates become denervated in mice that express mutations of human superoxide dismutase 1 (hSOD1), models of familial amyotrophic lateral sclerosis. This denervation is especially marked in fast limb muscles, and precedes death of motor neuron somata. This study used mice that expressed yellow fluorescent protein (YFP) in neurons to investigate changes in the morphology and function of axons and motor...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 22813866
DOI: 10.1016/j.nbd.2012.07.011
PMCID: PMC3461106

Genes

SOD1

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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