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Article

Altered intracellular Ca2+ homeostasis in nerve terminals of severe spinal muscular atrophy mice.

The Journal of neuroscience : the official journal of the Society for Neuroscience - 20 Jan 2010

Ruiz Rocío, Casañas Juan José, Torres-Benito Laura, Cano Raquel, Tabares Lucía

Abstract excerpt

Low levels of survival motor neuron (SMN) protein result in spinal muscular atrophy (SMA), a severe genetic disease characterized by motor impairment and premature lethality. Although SMN is a ubiquitous protein, motor neurons are much more vulnerable to low levels of SMN than other cells. To gain insight into the pathogenesis of SMA, we have compared synaptic function of motor terminals in wild-type and severe...

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Identifiers

PMID: 20089893
DOI: 10.1523/JNEUROSCI.4496-09.2010
PMCID: PMC6633088

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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