Article
Altered intracellular Ca2+ homeostasis in nerve terminals of severe spinal muscular atrophy mice.
The Journal of neuroscience : the official journal of the Society for Neuroscience - 20 Jan 2010
Ruiz Rocío, Casañas Juan José, Torres-Benito Laura, Cano Raquel, Tabares Lucía
Abstract excerpt
Low levels of survival motor neuron (SMN) protein result in spinal muscular atrophy (SMA), a severe genetic disease characterized by motor impairment and premature lethality. Although SMN is a ubiquitous protein, motor neurons are much more vulnerable to low levels of SMN than other cells. To gai...
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