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Article

Whi5 regulation by site specific CDK-phosphorylation in Saccharomyces cerevisiae.

PloS one - 1 Jan 2009

Wagner Michelle V, Smolka Marcus B, de Bruin Rob A M, Zhou Huilin, Wittenberg Curt, Dowdy Steven F

Abstract excerpt

The Whi5 transcriptional repressor is a negative regulator of G1 cell cycle progression in Saccharomyces cerevisiae and is functionally equivalent to the Retinoblastoma (Rb) tumor suppressor protein in mammals. In early G1, Whi5 binds to and inhibits SBF (Swi4/Swi6) transcriptional complexes. At Start, Cln:Cdc28 kinases phosphorylate and inactivate Whi5, causing its dissociation from SBF promoters and nuclear...

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Identifiers

PMID: 19172996
DOI: 10.1371/journal.pone.0004300
PMCID: PMC2627923

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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