Article
A Whi7-anchored loop controls the G1 Cdk-cyclin complex at start.
Molecular cell - 9 Jan 2014
Yahya Galal, Parisi Eva, Flores Alba, Gallego Carme, Aldea Martí
Abstract excerpt
Cells commit to a new cell cycle at Start by activation of the G1 Cdk-cyclin complex which, in turn, triggers a genome-wide transcriptional wave that executes the G1/S transition. In budding yeast, the Cdc28-Cln3 complex is regulated by an ER-retention mechanism that is important for proper cell size control. We have isolated small-cell-size CDC28 mutants showing impaired retention at the ER and premature...
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