Article
Whi5 phosphorylation embedded in the G1/S network dynamically controls critical cell size and cell fate.
Nature communications - 20 Apr 2016
Palumbo Pasquale, Vanoni Marco, Cusimano Valerio, Busti Stefano, Marano Francesca, Manes Costanzo, Alberghina Lilia
Abstract excerpt
In budding yeast, overcoming of a critical size to enter S phase and the mitosis/mating switch--two central cell fate events--take place in the G1 phase of the cell cycle. Here we present a mathematical model of the basic molecular mechanism controlling the G1/S transition, whose major regulatory feature is multisite phosphorylation of nuclear Whi5. Cln3-Cdk1, whose nuclear amount is proportional to cell size,...
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