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Article

Variants of the Sir4 Coiled-Coil Domain Improve Binding to Sir3 for Heterochromatin Formation in Saccharomyces cerevisiae.

G3 (Bethesda, Md.) - 3 Apr 2017

Samel Anke, Rudner Adam, Ehrenhofer-Murray Ann E

Abstract excerpt

Heterochromatin formation in the yeast Saccharomyces cerevisiae is characterized by the assembly of the Silent Information Regulator (SIR) complex, which consists of the histone deacetylase Sir2 and the structural components Sir3 and Sir4, and binds to unmodified nucleosomes to provide gene silencing. Sir3 contains an AAA+ ATPase-like domain, and mutations in an exposed loop on the surface of this domain abrogate...

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Share to Gene Silencing
Share to Genetic Loci
Share to Heterochromatin

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Silent Information Regulator Proteins, Saccharomyces cerevisiae

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Identifiers

PMID: 28188183
DOI: 10.1534/g3.116.037739
PMCID: PMC5386860

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