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Article

Expression profiling during ocular development identifies 2 Nlz genes with a critical role in optic fissure closure

26 Jan 2009

Abstract excerpt

The gene networks underlying closure of the optic fissure during vertebrate eye development are poorly understood. Here, we profile global gene expression during optic fissure closure using laser capture microdissected (LCM) tissue from the margins of the fissure. From these data, we identify a unique role for the C(2)H(2) zinc finger proteins Nlz1 and Nlz2 in normal fissure closure. Gene knockdown of nlz1 and/or...

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PMID: 19171890
DOI: 10.1073/pnas.0812017106

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