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Article

Inhibition of aurora kinases for tailored risk-adapted treatment of multiple myeloma

27 Jan 2009

Abstract excerpt

Genetic instability and cellular proliferation have been associated with aurora kinase expression in several cancer entities, including multiple myeloma. Therefore, the expression of aurora-A, -B, and -C was determined by Affymetrix DNA microarrays in 784 samples including 2 independent sets of 233 and 345 CD138-purified myeloma cells from previously untreated patients. Chromosomal aberrations were assessed by...

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PMID: 19171872
DOI: 10.1182/blood-2008-09-178350

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