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Article

Aurora kinase inhibitory VX-680 increases Bax/Bcl-2 ratio and induces apoptosis in Aurora-A-high acute myeloid leukemia.

Blood - 1 Mar 2008

Huang Xue-Fei, Luo Shao-Kai, Xu Jie, Li Juan, Xu Duo-Rong, Wang Li-Hui, Yan Min, Wang Xian-Ren, Wan Xiang-Bo, Zheng Fei-Meng, Zeng Yi-Xin, Liu Quentin

Abstract excerpt

Previously, we and others showed that mitotic Aurora-A kinase (Aur-A) was required for accurate mitotic entry and proper spindle assembly. In this study, we found that expression of Aur-A was markedly elevated in bone marrow mononuclear cells (BMMCs) obtained from a significant portion of de novo...

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Identifiers

PMID: 18160664
DOI: 10.1182/blood-2007-07-099325

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-18160664-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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