The centrosome index is a powerful prognostic marker in myeloma and identifies a cohort of patients that might benefit from aurora kinase inhibition

Abstract excerpt

Centrosome amplification is common in myeloma and may be involved in disease pathogenesis. We have previously derived a gene expression-based centrosome index (CI) that correlated with centrosome amplification and was an independent prognostic factor in a small cohort of heterogeneously treated patients. In this study, we validated the prognostic significance of the CI in 2 large cohorts of patients entered into...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Microtubule and mitosis dynamics
• Share to Multiple Myeloma Research and Treatments
• Share to Protein Degradation and Inhibitors