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Article

Clinical and biological implications of MYC activation: a common difference between MGUS and newly diagnosed multiple myeloma.

Leukemia - 1 Jun 2011

Chng W-J, Huang G F, Chung T H, Ng S B, Gonzalez-Paz N, Troska-Price T, Mulligan G, Chesi M, Bergsagel P L, Fonseca R

Abstract excerpt

Events mediating transformation from the pre-malignant monoclonal gammopathy of undetermined significance (MGUS) to multiple myeloma (MM) are unknown. We analyzed gene expression data sets generated on the Affymetrix U133 platform from 22 MGUS and 101 MM patients using gene-set enrichment analysis. Genes overexpressed in MM were enriched for cell cycle, proliferation and MYC activation gene sets. Upon dissecting...

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Identifiers

PMID: 21468039
DOI: 10.1038/leu.2011.53
PMCID: PMC3432644

Genes

MYC

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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