Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Aurora A kinase RNAi and small molecule inhibition of Aurora kinases with VE-465 induce apoptotic death in multiple myeloma cells

1 Jan 2008

Abstract excerpt

The expression of RHAMM and other centrosome-associated genes are known to correlate with the extent of centrosome amplification in multiple myeloma, and with poor prognosis. RHAMM has a significant interaction with TPX2, a protein which regulates the localization and action of Aurora A kinase (AURKA) at the spindle poles. AURKA is known to be a central determinant of centrosome and spindle function and is a...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Microtubule and mitosis dynamics
Share to Multiple Myeloma Research and Treatments
Share to Ubiquitin and proteasome pathways

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 18297535
DOI: 10.1080/10428190701824544

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Aurora A kinase RNAi and small molecule inhibition of Aurora kinases with VE-465 induce apoptotic death in multiple myeloma cellsPMID 18297535Read ↗

Inhibition of aurora kinases for tailored risk-adapted treatment of multiple myelomaSemantic proximity Read ↗

Targeting aurora kinases as therapy in multiple myeloma.Semantic proximity Read ↗

Identification of biomarkers and candidate regulators for multiple myeloma under the knockout of AURKASemantic proximity Read ↗

The centrosome index is a powerful prognostic marker in myeloma and identifies a cohort of patients that might benefit from aurora kinase inhibitionSemantic proximity Read ↗

Epigenetic silencing of miR-137 induces drug resistance and chromosomal instability by targeting AURKA in multiple myelomaSemantic proximity Read ↗

Receptor for Hyaluronan-Mediated Motility Correlates with Centrosome Abnormalities in Multiple Myeloma and Maintains Mitotic IntegritySemantic proximity Read ↗

Aurora kinase A is a target of Wnt/β-catenin involved in multiple myeloma disease progressionSemantic proximity Read ↗

ABL1 Kinase plays an important role in spontaneous and chemotherapy-induced genomic instability in multiple myelomaSemantic proximity Read ↗

Genetic Aberrations and Interaction of NEK2 and TP53 Accelerate Aggressiveness of Multiple MyelomaSemantic proximity Read ↗

Aurora kinase inhibitory VX-680 increases Bax/Bcl-2 ratio and induces apoptosis in Aurora-A-high acute myeloid leukemia.Semantic proximity Read ↗

Identification of PIKfyve kinase as a target in multiple myelomaSemantic proximity Read ↗

Kinome-wide RNAi studies in human multiple myeloma identify vulnerable kinase targets, including a lymphoid-restricted kinase, GRK6Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.