Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Mutations in three distinct loci cause resistance to peptide deformylase inhibitors in Bacillus subtilis.

Antimicrobial agents and chemotherapy - 1 Apr 2009

Duroc Yann, Giglione Carmela, Meinnel Thierry

Abstract excerpt

Bacillus subtilis mutants with resistance against peptide deformylase inhibitors were isolated. All showed a bypass of the pathway through mutations in three genes required for formylation of Met-tRNA(fMet), fmt, folD, and glyA. glyA corresponds to a yet uncharacterized locus inducing resistance. The bypass of formylation caused robust fitness reduction but was not accompanied by alterations of the transcription...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Amidohydrolases
Share to Anti-Bacterial Agents
Share to Bacillus subtilis

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Drug Resistance, Bacterial

Share to Enzyme Inhibitors

Share to Glycine Hydroxymethyltransferase

Share to Hydroxamic Acids

Share to RNA, Transfer, Met

Source

Open in PubMed Open full text

Identifiers

PMID: 19171795
DOI: 10.1128/AAC.01340-08
PMCID: PMC2663100

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Mutations in three distinct loci cause resistance to peptide deformylase inhibitors in Bacillus subtilis.PMID 19171795Read ↗

Peptide deformylase in Staphylococcus aureus: resistance to inhibition is mediated by mutations in the formyltransferase gene.Semantic proximity Read ↗

Reducing the fitness cost of antibiotic resistance by amplification of initiator tRNA genes.Semantic proximity Read ↗

Characterization of the Thermus thermophilus locus encoding peptide deformylase and methionyl-tRNA(fMet) formyltransferase.Semantic proximity Read ↗

Disruption of the gene for Met-tRNA(fMet) formyltransferase severely impairs growth of Escherichia coli.Semantic proximity Read ↗

Resistance of Streptococcus pneumoniae to deformylase inhibitors is due to mutations in defB.Semantic proximity Read ↗

Peptide deformylase as an antibacterial drug target: target validation and resistance development.Semantic proximity Read ↗

The mthA mutation conferring low-level resistance to streptomycin enhances antibiotic production in Bacillus subtilis by increasing the S-adenosylmethionine pool size.Semantic proximity Read ↗

Cyclophilin and Trigger Factor from <i>Bacillus </i><i>s</i><i>ubtilis</i> Catalyze in Vitro Protein Folding and Are Necessary for Viability under Starvation ConditionsSemantic proximity Read ↗

The role of peptide deformylase in protein biosynthesis: a proteomic study.Semantic proximity Read ↗

Genes involved in meso-diaminopimelate synthesis in Bacillus subtilis: identification of the gene encoding aspartokinase I.Semantic proximity Read ↗

Developmentally regulated cleavage of tRNAs in the bacterium Streptomyces coelicolor.Semantic proximity Read ↗

Actinonin, a Naturally Occurring Antibacterial Agent, Is a Potent Deformylase InhibitorSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.