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Article

Peptide deformylase in Staphylococcus aureus: resistance to inhibition is mediated by mutations in the formyltransferase gene.

Antimicrobial agents and chemotherapy - 1 Jul 2000

Margolis P S, Hackbarth C J, Young D C, Wang W, Chen D, Yuan Z, White R, Trias J

Abstract excerpt

Peptide deformylase, a bacterial enzyme, represents a novel target for antibiotic discovery. Two deformylase homologs, defA and defB, were identified in Staphylococcus aureus. The defA homolog, located upstream of the transformylase gene, was identified by genomic analysis and was cloned from chromosomal DNA by PCR. A distinct homolog, defB, was cloned from an S. aureus genomic library by complementation of the...

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Source

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Identifiers

PMID: 10858337
DOI: 10.1128/AAC.44.7.1825-1831.2000
PMCID: PMC89968

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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