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Article

Peptide deformylase as an antibacterial drug target: target validation and resistance development.

Antimicrobial agents and chemotherapy - 1 Apr 2001

Apfel C M, Locher H, Evers S, Takács B, Hubschwerlen C, Pirson W, Page M G, Keck W

Abstract excerpt

New inhibitors of peptide deformylase (PDF) which are very potent against the isolated enzyme and show a certain degree of antibacterial activity have recently been synthesized by our group. Several lines of experimental evidence indicate that these inhibitors indeed interfere with the target enzyme in the bacterial cell. (i) The inhibition of Escherichia coli growth could be counteracted by overexpression of PDF...

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Identifiers

PMID: 11257016
DOI: 10.1128/AAC.45.4.1058-1064.2001
PMCID: PMC90425

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PDF

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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