Article
The role of peptide deformylase in protein biosynthesis: a proteomic study.
Proteomics - 1 Mar 2003
Bandow Julia Elisabeth, Becher Dörte, Büttner Knut, Hochgräfe Falko, Freiberg Christoph, Brötz Heike, Hecker Michael
Abstract excerpt
Recently we investigated the influence of classical and emerging antibiotics on the proteome of Bacillus subtilis including in our studies actinonin, a potent novel inhibitor of peptide deformylase. The protein synthesis pattern under actinonin treatment changed so dramatically that a direct comparison to the control pattern was impossible. Dual channel imaging revealed that actinonin treatment caused the...
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