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Article

Reducing the fitness cost of antibiotic resistance by amplification of initiator tRNA genes.

Proceedings of the National Academy of Sciences of the United States of America - 2 May 2006

Nilsson Annika I, Zorzet Anna, Kanth Anna, Dahlström Sabina, Berg Otto G, Andersson Dan I

Abstract excerpt

Deformylase inhibitors belong to a novel antibiotic class that targets peptide deformylase, a bacterial enzyme that removes the formyl group from N-terminal methionine in nascent polypeptides. Using the bacterium Salmonella enterica, we isolated mutants with resistance toward the peptide deformylase inhibitor actinonin. Resistance mutations were identified in two genes that are required for the formylation of...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Share to Evolution, Molecular

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Source

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Identifiers

PMID: 16636273
DOI: 10.1073/pnas.0602171103
PMCID: PMC1459004

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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