Characterization of the Thermus thermophilus locus encoding peptide deformylase and methionyl-tRNA(fMet) formyltransferase.

doi:10.1128/jb.176.23.7387-7390.1994

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Article

Characterization of the Thermus thermophilus locus encoding peptide deformylase and methionyl-tRNA(fMet) formyltransferase.

Journal of bacteriology - 1 Dec 1994

Meinnel T, Blanquet S

Abstract excerpt

An Escherichia coli strain with thermosensitive expression of the gene encoding peptide deformylase (fms) has been constructed. At nonpermissive temperatures, this strain fails to grow. The essential character of the fms gene was further used to clone by heterologous complementation the locus cor...

Topics

Acyltransferases
Amidohydrolases
Amino Acid Sequence
Aminopeptidases
Carrier Proteins
Cloning, Molecular
Escherichia coli
Genes, Bacterial
Genes, Lethal
Hydroxymethyl and Formyl Transferases
Membrane Proteins
Molecular Sequence Data

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Mutation

Receptor, trkA

Restriction Mapping

Sequence Analysis, DNA

Sequence Homology, Amino Acid

Thermus thermophilus

Source

Open in PubMed Open full text

Identifiers

PMID: 7961514
DOI: 10.1128/jb.176.23.7387-7390.1994
PMCID: PMC197131

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-7961514-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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Characterization of the Thermus thermophilus locus encoding peptide deformylase and methionyl-tRNA(fMet) formyltransferase.PMID 7961514Read ↗

Disruption of the gene for Met-tRNA(fMet) formyltransferase severely impairs growth of Escherichia coli.Semantic proximity Read ↗

Mutations in three distinct loci cause resistance to peptide deformylase inhibitors in Bacillus subtilis.Semantic proximity Read ↗

Peptide deformylase as an antibacterial drug target: target validation and resistance development.Semantic proximity Read ↗

Peptide deformylase in Staphylococcus aureus: resistance to inhibition is mediated by mutations in the formyltransferase gene.Semantic proximity Read ↗

Truncation of peptide deformylase reduces the growth rate and stabilizes solvent production in Clostridium beijerinckii NCIMB 8052.Semantic proximity Read ↗

Structure-function relationships within the peptide deformylase family. Evidence for a conserved architecture of the active site involving three conserved motifs and a metal ion.Semantic proximity Read ↗

Complementation of an Escherichia coli polypeptide deformylase mutant with a gene from Clostridium acetobutylicum ATCC 824.Semantic proximity Read ↗

Resistance of Streptococcus pneumoniae to deformylase inhibitors is due to mutations in defB.Semantic proximity Read ↗

Expression of Escherichia coli methionyl-tRNA formyltransferase in Saccharomyces cerevisiae leads to formylation of the cytoplasmic initiator tRNA and possibly to initiation of protein synthesis with formylmethionine.Semantic proximity Read ↗

A cryptic ribosome binding site, false signals in reporter systems and avoidance of protein translation chaos.Semantic proximity Read ↗

Formylation is not essential for initiation of protein synthesis in all eubacteria.Semantic proximity Read ↗

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