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Cyclophilin and Trigger Factor from <i>Bacillus </i><i>s</i><i>ubtilis</i> Catalyze in Vitro Protein Folding and Are Necessary for Viability under Starvation Conditions

1 Sept 1998

Abstract excerpt

Cyclophilin (the product of the ppiB gene) and the trigger factor (the product of the tig gene) are the only cytosolic peptidyl-prolyl cis-trans isomerases that are known in Bacillus subtilis. Both enzymes catalyze the in vitro refolding of ribonuclease T1, a reaction that is limited in rate by a prolyl cis/trans isomerization. The efficiency of cyclophilin as a folding catalyst is only modest with a kcat/KM...

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PMID: 9748346
DOI: 10.1021/bi981253w

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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Cyclophilin and Trigger Factor from <i>Bacillus </i><i>s</i><i>ubtilis</i> Catalyze in Vitro Protein Folding and Are Necessary for Viability under Starvation ConditionsPMID 9748346Read ↗

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