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Article

Loop dynamics of the extracellular domain of human tissue factor and activation of factor VIIa.

Biophysical journal - 1 Jan 2009

Minazzo Agnese S, Darlington Reuben C, Ross J B Alexander

Abstract excerpt

In the crystal structure of the complex between the soluble extracellular domain of tissue factor (sTF) and active-site-inhibited VIIa, residues 91 and 92 in the Pro(79)-Pro(92) loop of sTF interact with the catalytic domain of VIIa. It is not known, however, whether this loop has a role in allosteric activation of VIIa. Time-resolved fluorescence anisotropy measurements of probes covalently bound to sTF mutants...

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Source

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Identifiers

PMID: 19167313
DOI: 10.1016/j.bpj.2008.10.018
PMCID: PMC2716462

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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