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Article

Crystal structures of uninhibited factor VIIa link its cofactor and substrate-assisted activation to specific interactions.

Journal of molecular biology - 20 Sept 2002

Sichler Katrin, Banner David W, D'Arcy Allan, Hopfner Karl-Peter, Huber Robert, Bode Wolfram, Kresse Georg-Burkhard, Kopetzki Erhard, Brandstetter Hans

Abstract excerpt

Factor VIIa initiates the extrinsic coagulation cascade; this event requires a delicately balanced regulation that is implemented on different levels, including a sophisticated multi-step activation mechanism of factor VII. Its central role in hemostasis and thrombosis makes factor VIIa a key tar...

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Identifiers

PMID: 12225752
DOI: 10.1016/s0022-2836(02)00747-7

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026. Prepared record publication-12225752-2026-09-01.1. Manifest publication-graph-cohort-2026-09-01.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 1 Sept 2026.

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Crystal structures of uninhibited factor VIIa link its cofactor and substrate-assisted activation to specific interactions.PMID 12225752Read ↗

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