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Article

Novel activating and inactivating mutations in the integrin beta1 subunit A domain.

The Biochemical journal - 1 Jun 2004

Barton Stephanie J, Travis Mark A, Askari Janet A, Buckley Patrick A, Craig Susan E, Humphries Martin J, Mould A Paul

Abstract excerpt

The ligand-binding activity of integrins is regulated by shape changes that convert these receptors from a resting (or inactive) state to an active state. However, the precise conformational changes that take place in head region of integrins (the site of ligand binding) during activation are not well understood. The portion of the integrin beta subunit involved in ligand recognition contains a von Willebrand...

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Identifiers

PMID: 14967067
DOI: 10.1042/BJ20031973
PMCID: PMC1224172

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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