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Article

TORC2, a coactivator of cAMP-response element-binding protein, promotes Epstein-Barr virus reactivation from latency through interaction with viral BZLF1 protein.

The Journal of biological chemistry - 20 Mar 2009

Murata Takayuki, Sato Yoshitaka, Nakayama Sanae, Kudoh Ayumi, Iwahori Satoko, Isomura Hiroki, Tajima Masako, Hishiki Takayuki, Ohshima Takayuki, Hijikata Makoto, Shimotohno Kunitada, Tsurumi Tatsuya

Abstract excerpt

Reactivation of the Epstein-Barr virus from latency is dependent on expression of the viral BZLF1 protein. The BZLF1 promoter (Zp) normally exhibits only low basal activity but is activated in response to chemical inducers such as 12-O-tetradecanoylphorbol-13-acetate and calcium ionophore. We found here that Transducer of Regulated cAMP-response Element-binding Protein (CREB) (TORC) 2 enhances Zp activity 10-fold...

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Identifiers

PMID: 19164291
DOI: 10.1074/jbc.M808466200
PMCID: PMC2658097

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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