Article
Null mutation of chloride channel 7 (Clcn7) impairs dental root formation but does not affect enamel mineralization.
Cell and tissue research - 1 Feb 2016
Guo Jing, Bervoets Theodore J M, Henriksen Kim, Everts Vincent, Bronckers Antonius L J J
Abstract excerpt
ClC-7, located in late endosomes and lysosomes, is critical for the function of osteoclasts. Secretion of Cl(-) by the ruffled border of osteoclasts enables H(+) secretion by v-H(+)-ATPases to dissolve bone mineral. Mice lacking ClC-7 show altered lysosomal function that leads to severe lysosomal storage. Maturation ameloblasts are epithelial cells with a ruffled border that secrete Cl(-) as well as endocytose...
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