Article
Characterization of acid flux in osteoclasts from patients harboring a G215R mutation in ClC-7.
Biochemical and biophysical research communications - 23 Jan 2009
Henriksen Kim, Gram Jeppe, Neutzsky-Wulff Anita Vibsig, Jensen Vicki Kaiser, Dziegiel Morten H, Bollerslev Jens, Karsdal Morten A
Abstract excerpt
The chloride-proton antiporter ClC-7 has been speculated to be involved in acidification of the lysosomes and the resorption lacunae in osteoclasts; however, neither direct measurements of chloride transport nor acidification have been performed. Human osteoclasts harboring a dominant negative mutation in ClC-7 (G215R) were isolated, and used these to investigate bone resorption measured by CTX-I, calcium release...
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