Sodium/hydrogen exchanger NHA2 in osteoclasts: subcellular localization and role in vitro and in vivo.

doi:10.1016/j.bone.2010.04.605

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Article

Sodium/hydrogen exchanger NHA2 in osteoclasts: subcellular localization and role in vitro and in vivo.

Bone - 1 Aug 2010

Hofstetter Willy, Siegrist Mark, Simonin Alexandre, Bonny Olivier, Fuster Daniel G

Abstract excerpt

NHA2 was recently identified as a novel sodium/hydrogen exchanger which is strongly upregulated during RANKL-induced osteoclast differentiation. Previous in vitro studies suggested that NHA2 is a mitochondrial transporter required for osteoclast differentiation and bone resorption. Due to the lack of suitable antibodies, NHA2 was studied only on RNA level thus far. To define the protein's role in osteoclasts in...

Topics

Animals
Antiporters
Bone and Bones
Cell Differentiation
Cell Line
Cell Membrane
Cell Polarity
Mice
Mice, Transgenic
Osteoclasts
Phenotype
Protein Transport
Subcellular Fractions
X-Ray Microtomography

Source

Open in PubMed

Identifiers

PMID: 20441802
DOI: 10.1016/j.bone.2010.04.605

Genes

LAMP1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026.

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