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PMEPA1 and NEDD4 control the proton production of osteoclasts by regulating vesicular trafficking.

FASEB journal : official publication of the Federation of American Societies for Experimental Biology - 1 Feb 2021

Hirata Hirohito, Xu Xianghe, Nishioka Kenichi, Matsuhisa Fumikazu, Kitajima Shuji, Kukita Toshio, Murayama Masatoshi, Urano Yasuteru, Miyamoto Hiroshi, Mawatari Masaaki, Kukita Akiko

Abstract excerpt

Osteoclast bone resorption activity is critically regulated to maintain bone homeostasis. Osteoclasts resorb bone by producing protons and acid hydrolase via lysosomal secretion, however, a detailed mechanism remains elusive. PMEPA1 is a vesicular membrane protein, which binds to the NEDD4 family member of ubiquitin ligases. We have previously reported that Pmepa1 is highly expressed in bone resorbing...

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PMID: 33484199
DOI: 10.1096/fj.202001795R

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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