The V-ATPase a3 Subunit: Structure, Function and Therapeutic Potential of an Essential Biomolecule in Osteoclastic Bone Resorption.

doi:10.3390/ijms22136934

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Article

The V-ATPase a3 Subunit: Structure, Function and Therapeutic Potential of an Essential Biomolecule in Osteoclastic Bone Resorption.

International journal of molecular sciences - 28 Jun 2021

Chu Anh, Zirngibl Ralph A, Manolson Morris F

Abstract excerpt

This review focuses on one of the 16 proteins composing the V-ATPase complex responsible for resorbing bone: the a3 subunit. The rationale for focusing on this biomolecule is that mutations in this one protein account for over 50% of osteopetrosis cases, highlighting its critical role in bone physiology. Despite its essential role in bone remodeling and its involvement in bone diseases, little is known about the...

Topics

Animals
Bone Resorption
Humans
Mutation
Osteoclasts
Osteopetrosis
Vacuolar Proton-Translocating ATPases

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Identifiers

PMID: 34203247
DOI: 10.3390/ijms22136934
PMCID: PMC8269383

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