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Article

SLC4A2, another gene involved in acid-base balancing machinery of osteoclasts, causes osteopetrosis.

Bone - 1 Feb 2023

Xue Jing-Yi, Ikegawa Shiro, Guo Long

Abstract excerpt

SLC4A2 belongs to the Na+-independent solute carrier family 4 (SLC4) of anion exchangers, which regulate electroneutral exchange of Cl- for HCO3- and mediate intra- and extra-cellular pH, chloride concentration and cell volume. Slc4a2 also participates in gastric acid secretion, spermatogenesis and osteoclastogenesis. During osteoclast differentiation, Slc4a2 is exclusively expressed at the contra-lacunar...

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Identifiers

PMID: 36343920
DOI: 10.1016/j.bone.2022.116603

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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