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Article

CLCN7, a gene shared by autosomal recessive and autosomal dominant osteopetrosis.

Bone - 1 Mar 2023

Stauber Tobias, Wartosch Lena, Vishnolia Svenja, Schulz Ansgar, Kornak Uwe

Abstract excerpt

After the discovery of abundant v-ATPase complexes in the osteoclast ruffled membrane it was obvious that in parallel a negative counter-ion needs to be transported across this membrane to allow for efficient transport of protons into the resorption lacuna. While different candidate proteins were discussed the osteopetrosis phenotype of Clcn7 knockout mice suggested that the chloride/proton-exchanger ClC-7 might...

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PMID: 36513280
DOI: 10.1016/j.bone.2022.116639

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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