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Article

Characterization of the bone phenotype in ClC-7-deficient mice.

Calcified tissue international - 1 Dec 2008

Neutzsky-Wulff Anita Vibsig, Karsdal Morten A, Henriksen Kim

Abstract excerpt

Mice deficient in the chloride channel ClC-7, which is likely involved in acidification of the resorption lacuna, display severe osteopetrosis. To fully characterize the osteopetrotic phenotype, the phenotypes of osteoclasts and osteoblasts were evaluated. ClC-7(-/-) mice and their corresponding wild-type littermates were killed at 4-5 weeks of age. Biochemical markers of bone resorption (CTX-I), osteoclast...

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Source

Identifiers

PMID: 18958510
DOI: 10.1007/s00223-008-9185-7

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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