Polymorphic mature microRNAs from passenger strand of pre-miR-146a contribute to thyroid cancer.

doi:10.1073/pnas.0812591106

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Article

Polymorphic mature microRNAs from passenger strand of pre-miR-146a contribute to thyroid cancer.

Proceedings of the National Academy of Sciences of the United States of America - 3 Feb 2009

Jazdzewski Krystian, Liyanarachchi Sandya, Swierniak Michal, Pachucki Janusz, Ringel Matthew D, Jarzab Barbara, de la Chapelle Albert

Abstract excerpt

Prior work has shown that heterozygosity G/C of single nucleotide polymorphism (SNP rs2910164) within the precursor of microRNA-146a predisposes to PTC (odds ratio = 1.62, P = 0.000007) although the mechanism was unclear. Here, we show that GC heterozygotes differ from both GG and CC homozygotes by producing 3 mature microRNAs: 1 from the leading strand (miR-146a), and 2 from the passenger strand (miR-146a*G and...

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Identifiers

PMID: 19164563
DOI: 10.1073/pnas.0812591106
PMCID: PMC2635764

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