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Article

A functional polymorphism in Pre-miR-146a gene is associated with prostate cancer risk and mature miR-146a expression in vivo.

The Prostate - 1 Apr 2010

Xu Bin, Feng Ning-Han, Li Peng-Chao, Tao Jun, Wu Deyao, Zhang Zheng-Dong, Tong Na, Wang Jin-Feng, Song Ning-Hong, Zhang Wei, Hua Li-Xin, Wu Hong-Fei

Abstract excerpt

BACKGROUND: A G > C polymorphism (rs2910164) which is located in the sequence of miR-146a precursor, results in a change from a G:U pair to a C:U mismatch in its stem region. To explore whether rs2910164 plays any role in prostate cancer (CaP), we analyzed the association between miR-146a polymorphism and risk of CaP and the expression of miR-146a with different genotypes in CaP tissues in southern Chinese Han...

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PMID: 19902466
DOI: 10.1002/pros.21080

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