Article
Common SNP in pre-miR-146a decreases mature miR expression and predisposes to papillary thyroid carcinoma.
Proceedings of the National Academy of Sciences of the United States of America - 20 May 2008
Jazdzewski Krystian, Murray Elizabeth L, Franssila Kaarle, Jarzab Barbara, Schoenberg Daniel R, de la Chapelle Albert
Abstract excerpt
Although papillary thyroid carcinoma (PTC) displays strong heritability, no predisposing germ-line mutations have been found. We show that a common G/C polymorphism (rs2910164) within the pre-miR-146a sequence reduced the amount of pre- and mature miR-146a from the C allele 1.9- and 1.8-fold, res...
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