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Article

Unusual circadian locomotor activity and pathophysiology in mutant CRY1 transgenic mice.

Neuroscience letters - 27 Feb 2009

Okano Satoshi, Akashi Makoto, Hayasaka Kiyoshi, Nakajima Osamu

Abstract excerpt

In the widely accepted molecular model underlying mammalian circadian rhythm, cryptochrome proteins (CRYs) play indispensable roles as inhibitive components of the CLOCK-BMAL1-mediated transcriptional-translational negative feedback loop. In order to clarify yet uncovered aspects of mammalian CRYs in vivo, we generated transgenic (Tg) mice ubiquitously overexpressing CRY1 as well as CRY1 having a mutation in the...

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Source

Identifiers

PMID: 19159659
DOI: 10.1016/j.neulet.2009.01.014

Genes

CRY1
BMAL1
CLOCK

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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