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Article

The duper mutation reveals previously unsuspected functions of Cryptochrome 1 in circadian entrainment and heart disease.

Proceedings of the National Academy of Sciences of the United States of America - 9 Aug 2022

Sisson Chip, Bahiru Michael Seifu, Manoogian Emily N C, Bittman Eric L

Abstract excerpt

The Cryptochrome 1 (Cry1)-deficient duper mutant hamster has a short free-running period in constant darkness (τDD) and shows large phase shifts in response to brief light pulses. We tested whether this measure of the lability of the circadian phase is a general characteristic of Cry1-null animals and whether it indicates resistance to jet lag. Upon advance of the light:dark (LD) cycle, both duper hamsters and...

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Identifiers

PMID: 35930669
DOI: 10.1073/pnas.2121883119
PMCID: PMC9371649

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