Article
Discovery and validation of colonic tumor-associated proteins via metabolic labeling and stable isotopic dilution.
Proceedings of the National Academy of Sciences of the United States of America - 6 Oct 2009
Huttlin Edward L, Chen Xiaodi, Barrett-Wilt Gregory A, Hegeman Adrian D, Halberg Richard B, Harms Amy C, Newton Michael A, Dove William F, Sussman Michael R
Abstract excerpt
The unique biology of a neoplasm is reflected by its distinct molecular profile compared with normal tissue. To understand tumor development better, we have undertaken a quantitative proteomic search for abnormally expressed proteins in colonic tumors from Apc(Min/+) (Min) mice. By raising pairs of Min and wild-type mice on diets derived from natural-abundance or (15)N-labeled algae, we used metabolic labeling to...
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