Article
Insights into the residence in lipid rafts of adenylyl cyclase AC8 and its regulation by capacitative calcium entry.
American journal of physiology. Cell physiology - 1 Mar 2009
Pagano Mario, Clynes Michael A, Masada Nanako, Ciruela Antonio, Ayling Laura-Jo, Wachten Sebastian, Cooper Dermot M F
Abstract excerpt
Adenylyl cyclases (ACs) are a family of critically important signaling molecules that are regulated by multiple pathways. Adenylyl cyclase 8 (AC8) is a Ca(2+) stimulated isoform that displays a selective regulation by capacitative Ca(2+) entry (CCE), the process whereby the entry of Ca(2+) into cells is triggered by the emptying of intracellular stores. This selectivity was believed to be achieved through the...
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