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Article

Phospho-selective mechanisms of arrestin conformations and functions revealed by unnatural amino acid incorporation and (19)F-NMR.

Nature communications - 8 Sept 2015

Yang Fan, Yu Xiao, Liu Chuan, Qu Chang-Xiu, Gong Zheng, Liu Hong-Da, Li Fa-Hui, Wang Hong-Mei, He Dong-Fang, Yi Fan, Song Chen, Tian Chang-Lin, Xiao Kun-Hong, Wang Jiang-Yun, Sun Jin-Peng

Abstract excerpt

Specific arrestin conformations are coupled to distinct downstream effectors, which underlie the functions of many G-protein-coupled receptors (GPCRs). Here, using unnatural amino acid incorporation and fluorine-19 nuclear magnetic resonance ((19)F-NMR) spectroscopy, we demonstrate that distinct receptor phospho-barcodes are translated to specific β-arrestin-1 conformations and direct selective signalling. With...

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Identifiers

PMID: 26347956
DOI: 10.1038/ncomms9202
PMCID: PMC4569848

Genes

GRK2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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