Article
A mutation in CHN-1/CHIP suppresses muscle degeneration in Caenorhabditis elegans.
Developmental biology - 1 Dec 2007
Nyamsuren Oyunbileg, Faggionato Davide, Loch Wiebke, Schulze Ekkehard, Baumeister Ralf
Abstract excerpt
Duchenne muscular dystrophy (DMD) is one of the most severe X-linked, inherited diseases of childhood, characterized by progressive muscle wasting and weakness as the consequence of mutations in the dystrophin gene. The protein encoded by dystrophin is a huge cytosolic protein that links the intracellular F-actin filaments to the members of the dystrophin-glycoprotein-complex (DGC). Dystrophin deficiency results...
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