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Article

Absent sleep EEG spindle activity in GluA1 (Gria1) knockout mice: relevance to neuropsychiatric disorders.

Translational psychiatry - 14 Aug 2018

Ang Gauri, McKillop Laura E, Purple Ross, Blanco-Duque Cristina, Peirson Stuart N, Foster Russell G, Harrison Paul J, Sprengel Rolf, Davies Kay E, Oliver Peter L, Bannerman David M, Vyazovskiy Vladyslav V

Abstract excerpt

Sleep EEG spindles have been implicated in attention, sensory processing, synaptic plasticity and memory consolidation. In humans, deficits in sleep spindles have been reported in a wide range of neurological and psychiatric disorders, including schizophrenia. Genome-wide association studies have suggested a link between schizophrenia and genes associated with synaptic plasticity, including the Gria1 gene which...

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Identifiers

PMID: 30108203
DOI: 10.1038/s41398-018-0199-2
PMCID: PMC6092338

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