Article

Purkinje cell dysfunction causes disrupted sleep in ataxic mice

2023-07-03

Abstract excerpt

Purkinje cell dysfunction causes movement disorders such as ataxia, however, recent evidence suggests that Purkinje cell dysfunction may also alter sleep regulation. Here, we used an ataxia mouse model generated by silencing Purkinje cell neurotransmission ( L7 Cre ;Vgat fx/fx ) to better understand how cerebellar dysfunction impacts sleep physiology. We focused our analysis on sleep architecture and electrocor...

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Literature Corpus work: 0908ff4d-7bbd-5117-b376-07811e26b306
DOI: 10.1101/2023.07.03.547586

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