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Article

Sleep and Sleep Regulation in Normal and Prion Protein-Deficient Mice

1 Mar 1997

Abstract excerpt

Mice are the preferred mammalian species for genetic investigations of the role of proteins. The normal function of the prion protein (PrP) is unknown, although it plays a major role in the prion diseases, including fatal familial insomnia. We investigated its role in sleep and sleep regulation by comparing baseline recordings and the effects of sleep deprivation in PrP knockout mice (129/SV) and wild-type...

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PMID: 9030645
DOI: 10.1523/jneurosci.17-05-01869.1997

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