Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Cutting edge: histamine receptor H4 activation positively regulates in vivo IL-4 and IFN-gamma production by invariant NKT cells.

Journal of immunology (Baltimore, Md. : 1950) - 1 Feb 2009

Leite-de-Moraes Maria C, Diem Séverine, Michel Marie-Laure, Ohtsu Hiroshi, Thurmond Robin L, Schneider Elke, Dy Michel

Abstract excerpt

Histamine (HA) is a biogenic amine with multiple activities in the immune system. In this study we demonstrate that histamine-free histidine decarboxylase-deficient (HDC(-/-)) mice present a numerical and functional deficit in invariant NK T (iNKT) cells as evidenced by a drastic decrease of IL-4 and IFN-gamma production. This deficiency was established both by measuring cytokine levels in the serum and...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cross-Linking Reagents
Share to Histamine

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Interferon-gamma

Share to Interleukin-4

Share to Lymphocyte Count

Share to Natural Killer T-Cells

Share to Receptors, Antigen, T-Cell

Share to Receptors, G-Protein-Coupled

Source

Identifiers

PMID: 19155466
DOI: 10.4049/jimmunol.182.3.1233

Genes

HDC

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Cutting edge: histamine receptor H4 activation positively regulates in vivo IL-4 and IFN-gamma production by invariant NKT cells.PMID 19155466Read ↗

Histamine receptor 2 modifies iNKT cell activity within the inflamed lung.Semantic proximity Read ↗

The role of histamine H 4 receptor in immune and inflammatory disordersSemantic proximity Read ↗

Mice lacking histidine decarboxylase exhibit abnormal mast cells.Semantic proximity Read ↗

Negative regulatory effect of histamine in DNFB-induced contact hypersensitivity.Semantic proximity Read ↗

Histamine H₂ receptor signaling × environment interactions determine susceptibility to experimental allergic encephalomyelitis.Semantic proximity Read ↗

The role of iNKT cells on the phenotypes of allergic airways in a mouse model.Semantic proximity Read ↗

New developments in the use of histamine and histamine receptors.Semantic proximity Read ↗

Label-free cell phenotypic profiling of histamine H4R receptor and discovery of non-competitive H4R antagonist from natural products.Semantic proximity Read ↗

Human Memory Th17 Cells Express a Functional Histamine H4 ReceptorSemantic proximity Read ↗

Histamine deficiency promotes inflammation-associated carcinogenesis through reduced myeloid maturation and accumulation of CD11b+Ly6G+ immature myeloid cells.Semantic proximity Read ↗

Histamine deficiency suppresses murine haptoglobin production and modifies hepatic protein tyrosine phosphorylation.Semantic proximity Read ↗

Autoimmune disease-associated histamine receptor H1 alleles exhibit differential protein trafficking and cell surface expression.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.